The Assault Commander is an enemy in Duke Nukem Forever.
The Assault Commander is a flying enemy (fatass blob) that fires rockets from its rectum while constantly moving. In addition, it can use its blades as a weapon by charging towards the player, making them deadly in melee as well as ranged combat. They also have the ability to instantly mutate humans into Pig Cops, using the weapon on one of their arms.
When you first encounter the Assault Commander in The Lady Killer: Part 3 you have a very limited arsenal: an M1911, a shotgun and newly found laser tripbombs. These are the key. When the Assault Commander appears he turns two EDF soldiers into Pig Cops armed with shotguns; dispose of them and then it's business. The trick is to throw the tripbombs high, one at a time and run around so the AC chases you, setting off the bombs. Do this a few times and you're done!
Future encounters allow more advanced weaponry, such as the devastator, RPG, or shrink ray. One shot from a shrink ray will allow you to squish the Assault Commander provided it isn't flying too high above you.