Upon being materialized from the transmat tube from the previous episode, there will be a grenade launcher and ammo for it right beside the lift. Duke won't have to walk far to encounter the boss, a large green stationary torso of cyborg which is blocking access to the other side. Upon seeing Duke, it will "regurgitate" slime from its mouth.
The only weapon Duke can use to defeat it is with the Grenade launcher, where the grenades should be lobbed at the back of the head, which is its weak spot. After this is done five times, the cyborg's head will explode as well as letting Duke to pass through the room and head to another transmat tube.